At present malaria remains a very serious problem for modern medicine, despite advances in diagnosis and treatment.
- 1 Statistics
- 2 Which way out of this situation?
- 3 Types of malaria parasites
- 4 Symptoms of malaria
- 5 How do you get infected?
- 6 resistance What is the disease?
- 7 Treatment of malaria
- 8 New approaches
According to the information to the World Health Organization in the world (WHO), every year there are nearly 220 million. cases of infection by the disease, with about 700 thousand people die.
This trend is explained by the fact that as yet there is no vaccine that could effectively protect people from malaria.This is quite difficult to block all the ways of development of the pathogen and its transmission by mosquitoes from infected person healthy.
Which way out of this situation?
It was noted that the spread of malaria can be suspended by means of enzyme inhibitors BKIs.This reduces the likeli
Types of malaria parasites
known four species of malaria parasites:
Moreover, in primates there is still 26 species of parasites.They cause disease in humans, but very rarely.
Symptoms of malaria
Despite the variety of species of parasites clinical picture of the disease is always difficult and the prognosis is unpredictable, because often there are severe complications that leave behind the chronic changes in human health.
disease begins always with fever and shaking chills, pain in the joints (arthralgia), anemia, increased spleen and liver (hepatosplenomegaly).
The blood test (usually taken thick drop of blood) are determined by the affected red blood cells plasmodium plasmodium that is found in red blood cells themselves.
If you do not carry out any remedial measures, malaria is a deadly disease.
How do you get infected?
person infected by the bite of mosquitoes of the genus Anopheles.Saliva contains insect Plasmodium sporozoites ( pathogen malaria), which penetrate the human circulatory system.After that, the sporozoites are introduced into the liver, where the one being formed thousands of merozoites.This form goes into the blood and red blood cells are affected.Merozoites thus become gametocytes. reached this level of development, the parasite can infect mosquitoes by using healthy people, once again becoming a huge number of sporozoites.
So spread the disease.
resistance What is the disease?
Medicine has developed several methods for controlling the disease:
- mosquito destruction in their favorite habitat, where the insect's breeding cycle.For this special chemical compounds used;
- disease diagnosed during and infected patients hospitalized immediately;
Treatment of malaria
The most commonly used combination therapy consisting of two drugs: artemisinin and primaquine.Primaquine destroys the mature forms of the parasite, and artemisinin - immature.Although effective, treatment has disadvantages:
- effects of drugs are quite toxic.Mainly affected the gastrointestinal tract;
- drugs may have no effect on the transmission of Plasmodium by mosquitoes.
Scientists from Britain and the United States conducted a study which aims to find out the effectiveness of some enzyme inhibitors in the treatment of malaria and reducing the spread of it in the world.
Previous research has led to what has been revealed of great importance to every stage of the development of Plasmodium specific kinases called calcium-dependent protein kinases (CDPKs). With their help, provided the penetration mechanisms of the parasite in the human body, the motor activity of the plasmodium and the possibility of penetration into the blood from the liver.
established that BKIs inhibitors are specific and inhibit kinase CDPK4, which is responsible for the intensity of malaria transmission.Moreover, these drugs do not cause side effects and long-term use can not have a toxic effect on human body.
It is known that the enzyme inhibitors BKIS, improve and expand the range of methods for malaria control not only in connection with the drug effects on Plasmodium, but also due to the slowdown being spread this insidious and dangerous disease.