drug "Corinfar" refers to calcium channel blockers, and this due to the indications for use.That is, it prevents the passage of Ca2 + (calcium ion) through the channels in the cell membranes.As a result, it decreases the tonus of vascular walls is necessary at high pressure to reduce it.Corinfar has antianginal effect, ie prevents or relieves angina, coronary insufficiency cures for coronary disease.
main indications for use "Corinfar" drug - is arterial hypertension (primary and secondary), angina, variant angina.Thus, Corinfar prescribed pressure and heart disease.These are the main indications for acceptance corinfar.
composition and the form of
corinfar The active substance is nifedipine.Among the auxiliary components, potato starch, lactose monohydrate, povidone, and magnesium stearate.
release form drug - coated tablets.Buy agent may be in blister packs (10 pcs.), Or in vials of dark glass (50 pcs. Or 100 pcs.).
Pharmaceutical action and pharmacokinetics
Corinfar characterized by a high degree of absorption - up to 90%, the ability to absorb from 50 to 70%.Food intake increases the bioavailability.
drug penetrates through the placental and blood-brain barrier, enters the breast milk.Undergoes a complete metabolism in the liver.
Kidneys derived from 60 to 80% of active ingredient, with bile - about 20%.The half-life is 2-5 hours.
corinfar Long-term use (2-3 months) leads to development of tolerance to the drug.
- Hypotension (upper pressure decrease to 90 mm Hg. Art.).
- Decompensated heart failure (congestive heart failure).
- Marked narrowing of the aortic valve (stenosis).
- Unstable angina.
- acute left ventricular failure, severe.
- Acute vascular insufficiency (collapse).
- first four weeks after the acute myocardial infarction.
- first trimester of pregnancy.
- Individual intolerance to nifedipine or other components.
drug "Corinfar" used with caution in the following conditions:
- hypertrophic obstructive cardiomyopathy;
- mitral valve stenosis;
- pronounced tachycardia (rapid pulse) or bradycardia (slow heart rate);
- malignant hypertension (persistent and significant increase in pressure);
- hepatic and renal failure;
- severe violations of cerebral circulation;
- infarction with left ventricular heart failure;
- volume decreases the circulation of blood (hypovolemia);
- obstruction of the digestive tract;
- during pregnancy (the second and third trimesters);
- under the age of 18 years.
drug "Corinfar" has a lot of side effects from the various systems of the body.
central nervous system .Fatigue, weakness, dizziness, headache, somnolence.Long-term use "Corinfar" drug can cause paresthesias (numbness) of limbs, tremor (shaking), parkinsonian disorders (shuffling gait, poor coordination of movements, masklike face, trembling of the hands and fingers), depression.
Cardiovascular system.Arrhythmia, tachycardia, palpitations, edema (shins, ankles, feet), the development of heart failure, decreased blood pressure, flushing of blood, feeling the heat.There may be angina and myocardial (rarely), in which case the application need to put an end to the drug.
Gastrointestinal tract.Dry mouth, nausea, diarrhea or constipation, flatulence, increased appetite.Long-term use of pills "Corinfar" may lead to a breach of the liver.
Musculoskeletal .Swelling of joints, arthritis, myalgias, cramping hands and feet.
Agencies hematopoiesis .Leukopenia, anemia, thrombocytopenia, agranulocytosis, thrombocytopenic purpura.
Urinary system.The increase in daily urine volume, deterioration in renal function in patients with renal insufficiency.
Allergies .Hives, itching, dermatitis, skin rashes.
How to take?
What if the aching heart and hard to breathe?
drug "Corinfar" Inside, with liquid squeezed enough with plenty of water.It is recommended to drink tablets after meals.When receiving the drug with food increases drug absorption time from the gastrointestinal tract, but does not decrease the amount.The dosage regimen
Corinfar drug, dosage, duration of treatment depends on the diagnosis, severity of the disease, the patient's reaction to the action of the active substance and defined only by the attending physician individually.
Overdose In case of overdose there is a headache, tachycardia or bradycardia, decrease in pressure occurs, blushing face, develop bradyarrhythmia.In severe cases, possible loss of consciousness or coma onset.If poisoning "Corinfar" drug prescribed gastric lavage, in some cases, the small intestine.
While receiving means "Corinfar" you can not drink alcoholic beverages.Cancel the drug gradually.Taking the pill, you should use caution when operating machinery, driving during transport and for any actions that require high concentration.
most famous drug analogues: Kordafen, Adalat, Kordafleks, cordipin, fenigidin, Nifecard, Nifedipine, Sanfidipin.All of them are composed of the same active ingredient - nifedipine.